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. 2014 Aug;141(15):3003–3012. doi: 10.1242/dev.105924

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Growth and development of the facial prominences is disrupted in talpid² mutants. Day 7 control (n=10) and talpid² (n=4) embryos. (A,B) Frontal views of facial prominences; frontonasal (fnp), maxillary (mxp) and mandibular prominences (mnp). Bilateral clefting in talpid² embryos (white arrows in B). (C,D) Palatal views show increased patency of both the primary and secondary palate of talpid² embryos (dotted yellow line). (E,F) Dorsal view of the mnp. The mnp of talpid² embryos is clefted (white arrow in F) and exhibits hypoglossia (dotted yellow line). (G) Quantitative analysis of fnp and mxp growth. For fnp length, *P<0.02; for fnp width, *P<0.02; for infranasal width, *P<0.04; for patent palate, *P<0.02. t, tongue. Data are mean±s.e.m. Scale bars: 1 mm (A-F).