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. 2014 Aug;141(15):3003–3012. doi: 10.1242/dev.105924

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Post-translational processing of GLI2 is disrupted in talpid² mutants. (A) Western blot analysis for GLI2 in HH 25 facial prominences and limbs. Both full-length GLI2 protein (GLI2-185) and cleaved GLI2 (GLI2-78) are present. Gel mobility of GLI2-185 is higher in talpid² (compare black and white asterisks). (B) Ratio of GLI2-185 to GLI2-78 is increased in talpid². *P<0.05. Data are mean±s.e.m. (C) Nuclear fractionation detects both GLI2 activator (GLI2A) and GLI2 repressor (GLI2R). LAMIN and GAPDH expression mark the nuclear (N) and cytosolic (C) compartment. T, total protein.