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Post-translational processing of GLI3FL is disrupted in talpid2. (A) Western blot analysis for GLI3 in HH 25 facial prominences and limbs. Both full-length GLI3 protein (GLI3-190) and cleaved GLI3 (GLI3-83) are present. (B) Ratio of GLI3-190 to GLI3-83 is increased in talpid2. *P<0.05. (C) Nuclear fractionation detects both GLI3 activator (GLI3A) and GLI3 repressor (GLI3R). LAMIN and GAPDH expression mark the nuclear (N) and cytosolic (C) compartment. T, total protein.
