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. 2014 Oct;141(20):3819–3833. doi: 10.1242/dev.104471

Fig. 7.

Fig. 7.

Roles of T-box genes during stem/progenitor cell self-renewal and differentiation. (A) The self-renewal of stem cell or progenitor cell populations is affected by several T-box transcription factors (highlighted), both in the maintenance of cell lines in vitro (left) and in cell populations within the embryo or adult in vivo (right). (B) Studies of stem or progenitor cells have shown that T-box transcription factors are also important for driving the differentiation of specific lineages (arrows), sometimes while inhibiting alternative differentiation pathways, both in vitro and in vivo. Several direct target genes involved in the differentiation pathways are indicated along the arrow path. ESC, embryonic stem cell; EpiSC, epiblast stem cell; ExEn, extraembryonic endoderm; FHF, first heart field; hESC, human embryonic stem cell; HF-SC, hair follicle stem cell; IPC, intermediate progenitor cell; iPSC, induced pluripotent stem cell; NSC, neural stem cell; SHF, second heart field; SSC, spermatogonial stem cell; TE, trophectoderm; TSC, trophoblast stem cell.