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. 2014 Sep;141(18):3583–3593. doi: 10.1242/dev.111740

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Synergistic pouch and cartilage defects in compound wnt11r; fgf8a mutants. (A-D) Alcama immunohistochemistry (green) labeled five pouches (p1-p5) in wild-type embryos at 34 hpf. Compared with the mild reductions of pouches in wnt11r or fgf8a single mutants, compound wnt11r^−/−; fgf8a^−/− mutants had a near complete loss of pouches. Sensory ganglia are indicated with red asterisks. (E-H) Dissections of facial cartilage at 5 dpf. Wild type had five CBs on each side, wnt11r and fgf8a single mutants had variable fusions and losses of on average one CB and compound wnt11r^−/−; fgf8a^−/− mutants lost multiple CBs. (I) Quantification of defects. Number of embryos examined (pouches, CBs): wild type (106, 102), wnt11r^−/− (66, 57), fgf8a^−/− (68, 98), and wnt11r^−/−; fgf8a^−/− (24, 20). Data represent mean±s.e.m. ***P<0.001 relative to fgf8a mutants alone. Scale bar: 40 μm (A-D).