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. 2014 Oct 15;6:276. doi: 10.3389/fnagi.2014.00276

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Copyright © 2014 Hetz, Acikgoez, Moll, Jahnke, Robitzki, Metzger and Metzger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of gene and protein expression of markers characteristic for ENS. Analysis of a panel of markers characteristic for ENS confirms that the plexus from aged donors show significant decrease of neurotrophin receptor p75 and Ret receptor (NGFR and RET, identifying ENS plexus) and nitric oxide synthase (NOS1, labeling a main neuronal subpopulation), whereas other neural subtypes were up-regulated like choline acetyltransferase (CHAT). Other genes such as tyrosine hydroxylase (TH) or the glial marker S100 calcium binding protein B (S100B) were not significantly regulated. These data suggest general alterations of ENS integrity during aging. Depending on gut age and region, different subpopulations seem to be differentially affected. ^*P ≤ 0.05 and 0.05 <^§P < 0.1. DC, distal colon; PC, proximal colon; ns, not significant.