Table 1.
Characterization of sodium channels Nav1.1-1.9.
| Nan (Gene symbol) | TTX-sensitivity | CNS | PNS | ENS nerval plexus | Muscle | References |
|---|---|---|---|---|---|---|
| Nav1.1 (SCN1A) | + | ++ | + | − | − | Noda et al., 1986; Felts et al., 1997; Strege et al., 2003; Bartoo et al., 2005; Sage et al., 2007 |
| Nav1.2 (SCN2A) | + | ++ | + | + | n.d. | Noda et al., 1986; Felts et al., 1997; Holm et al., 2002; Hanani et al., 2004; Bartoo et al., 2005 |
| Nav1.3 (SCN3A) | + | ++ | + | + | n.d. | Kayano et al., 1988; Beckh, 1990; Felts et al., 1997; Hanani et al., 2004; Bartoo et al., 2005; Sage et al., 2007 |
| Nav1.4 (SCN4A) | + | + | + | + | + | Deshpande et al., 2002; Ou et al., 2002; Hanani et al., 2004; Bartoo et al., 2005; Candenas et al., 2006; Sage et al., 2007 |
| Nav1.5 (SCN5A) | − | + | + | + | + | Deshpande et al., 2002; Holm et al., 2002; Ou et al., 2002; Strege et al., 2003; Hanani et al., 2004; Bartoo et al., 2005; Candenas et al., 2006; Sage et al., 2007 |
| Nav1.6 (SCN8A) | + | ++ | + | + | n.d. | Schaller et al., 1995; Felts et al., 1997; Raman et al., 1997; Krzemien et al., 2000; Tzoumaka et al., 2000; Bartoo et al., 2005 |
| Nav1.7 (SCN9A) | + | + | ++ | + | n.d. | Hanani et al., 2004; Bartoo et al., 2005; Candenas et al., 2006; Sage et al., 2007 |
| Nav1.8 (SCN10A) | − | − | + | − | − | Ou et al., 2002; Rugiero et al., 2003; Hanani et al., 2004; Bartoo et al., 2005; Sage et al., 2007 |
| Nav1.9 (SCN11A) | + | + | + | + | + | Ou et al., 2002; Rugiero et al., 2003; Hanani et al., 2004; Bartoo et al., 2005; Candenas et al., 2006; Sage et al., 2007; Copel et al., 2013 |
DRG, dorsal root ganglia; n.d., not determined.