Figure 3.

HCV expression and irf-1 ablation affect the lymphocyte population. T-cell and B-cell proliferation in irf-1^+/+ CN2 mice, irf-1^−/− CN2 mice, and WT mice. CD3⁺, CD45R⁺, CD4⁺, CD8⁺, and T-cell receptor–positive cells from age-matched irf-1^−/− CN2, irf-1^+/+ CN2, and WT mice with hyperplasia were analyzed by fluorescence-activated cell sorting. Lymphocytes were prepared from CN2-8 and WT littermates at the age of 16 months, after administration of AxCANCre for 400 days.