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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Gastroenterology. 2009 Apr 9;137(1):285–29711. doi: 10.1053/j.gastro.2009.03.061

Figure 5.

Figure 5

HCV protein expression alters the cytokine profile. (A) The serum IL-2, IL-4, IL-10, and IL-12 levels in irf-1+/+ CN2 (Tg+) and irf-1+/+ WT mice were measured by enzyme-linked immunosorbent assay. (B) The serum IL-2, IL-4, IL-10, and IL-12 levels in irf-1−/− CN2 (Tg+) and irf-1−/− WT mice were measured by enzyme-linked immunosorbent assay. The P values are based on comparisons of the mean cytokine concentrations. (C and D) Relationship between the IL-2 or IL-10 concentration in the serum and the spleen weights of (C) CN2irf-1+/+ or (D) CN2irf1−/− mice with progressive lymphoproliferation. The numbers of points in the graphs correspond to the numbers of tested animals. (E) Bcl-2 protein levels in the lymph nodes of irf-1+/+ (WT) and irf-1−/− transgenic (CN2) (Tg+) and WT mice on days 0, 400, and 500 after the administration of AxCANCre. Bcl-2 migrates at 26 kilodaltons. β-Actin was used as a loading control.