. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Mol Nutr Food Res. 2014 Jul 28;58(10):2023–2035. doi: 10.1002/mnfr.201400068

Table 1.

Per-allele (log-additive) associations^a) between variants in genes in 1-C transfer and purine and pyrimidine metabolism pathways and risk of ovarian carcinoma: 13,410 cases (5,813 high-grade serous-only) and 22,635 controls of European ancestry in OCAC.

		All cases					High-Grade Serous cases
Gene	SNP	OR	95% CI lower	95% CI upper	P-value	P-value (SNP*site interaction)	OR	95% CI lower	95% CI upper	P-value	P-het^b)
1-C transfer
DNMT3B	rs4911256	1.04	1.00	1.07	0.025	0.88	1.04	0.99	1.09	0.082	0.26
SHMT1	rs669340	0.96	0.93	0.99	0.021	0.58	0.94	0.90	0.98	0.006	0.09
SHMT1	rs4925179	0.97	0.93	1.00	0.040	0.69	0.95	0.91	1.00	0.037	0.21
Purine metabolism
ATIC	pos215884573	1.05	1.00	1.10	0.036	0.34	1.08	1.01	1.14	0.016	0.08
IMPD2	rs4974081	0.96	0.93	1.00	0.043	0.68	0.96	0.92	1.01	0.169	0.66
Pyrimidine metabolism
AK3^c)	rs691941	0.95	0.91	0.99	0.020	0.13	0.94	0.89	1.00	0.061	0.11
DPYD	rs828054	1.06	1.03	1.10	0.0001	0.80	1.07	1.03	1.12	0.002	0.02
DPYD	rs11587873	0.92	0.89	0.96	0.00006	0.08	0.93	0.88	0.98	0.008	0.01
DPYD	rs12120388	0.94	0.91	0.97	0.0004	0.83	0.94	0.90	0.98	0.004	0.02
DPYD	rs676686	1.06	1.02	1.09	0.001	0.85	1.07	1.02	1.12	0.003	0.01
DPYD	rs914959	1.05	1.01	1.08	0.007	0.65	1.05	1.00	1.10	0.028	0.08
DPYD	rs7537668	1.04	1.01	1.08	0.011	0.61	1.05	1.01	1.10	0.026	0.03
DPYD	rs4128474	0.95	0.90	1.00	0.031	0.99	0.96	0.90	1.02	0.178	0.34
DPYD	rs494271	1.04	1.00	1.07	0.034	0.80	1.04	1.00	1.10	0.052	0.02
DPYD	rs6678858	0.95	0.91	1.00	0.034	1.00	0.97	0.91	1.03	0.321	0.70
DPYD	rs7555294	0.96	0.92	1.00	0.041	0.90	0.97	0.91	1.02	0.229	0.73
DPYD	rs4434871	0.95	0.91	1.00	0.041	0.97	0.98	0.92	1.04	0.491	0.65
DPYD	rs7522938	1.03	1.00	1.07	0.048	0.72	1.02	0.98	1.07	0.330	0.26
DHODH^d)	rs3213423	1.05	1.01	1.09	0.018	0.10	1.01	0.96	1.06	0.757	0.77
DHODH	rs11864453	0.97	0.93	1.00	0.037	0.19	0.97	0.93	1.01	0.170	0.54
NME6	rs7651161	0.97	0.94	1.00	0.048	0.73	0.96	0.92	1.01	0.089	0.49
RRM2B	pos103299244	2.67	1.15	6.19	0.022	0.92	2.42	0.78	7.48	0.126	0.27
TYMS	pos656897	1.27	1.09	1.48	0.002	0.27	1.31	1.07	1.62	0.010	0.008

^a)

Adjusted for age (continuous), study stratum and the first five eigenvalues from principal components analysis; P < 0.05.

^b)

P-value for tumor heterogeneity comparing odds ratios between all controls and each of high-grade serous OC, low-grade serous OC, mucinous OC, endometrioid OC and clear cell OC.

^c)

SNP is located 3′ upstream of gene.

^d)

SNP is located in flanking 5′ region of gene; all other SNPs are located in introns; ‘pos’ SNPs are novel and identified by chromosomal position.