. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Mol Nutr Food Res. 2014 Jul 28;58(10):2023–2035. doi: 10.1002/mnfr.201400068

Table 2.

Associations^a) between variants in genes in 1-C transfer and purine and pyrimidine metabolism pathways and risk of ovarian carcinoma stratified by total folate intake: 2,281 cases and 3,444 controls of European ancestry participants in OCAC.

		Total folate Intake ≤ 484 μg/d										Total folate intake > 484 μg/d
		Controls			Cases							Controls			Cases
Gene	SNP	AA^b)	AB	BB	AA	AB	BB	OR	95% CI lower	95% CI upper	P value	AA	AB	BB	AA	AB	BB	OR	95% CI lower	95% CI upper	P value	P int^c)
1-C transfer
SHMT1^d)	rs56001517	1506	232	8	991	162	5	1.05	0.85	1.29	0.656	1475	215	6	1011	108	2	0.70	0.55	0.89	0.004	0.012
SHMT1	rs7216214	1394	335	18	907	237	15	1.08	0.91	1.28	0.396	1341	340	13	925	182	12	0.76	0.63	0.92	0.004	0.006
SHMT1	rs4925179	711	786	250	501	526	131	0.88	0.79	0.99	0.03	703	775	217	469	509	144	1.03	0.92	1.16	0.606	0.048
SHMT1	rs2273026	1409	323	15	931	213	15	1.03	0.86	1.22	0.767	1363	322	11	938	172	11	0.77	0.64	0.94	0.008	0.027
Purine metabolism
IMPD1^d)	rs6948333	991	653	101	624	453	77	1.09	0.96	1.23	0.171	950	637	105	638	435	46	0.91	0.80	1.03	0.139	0.039
PFAS	rs11649742	1049	606	92	721	378	60	0.93	0.82	1.06	0.257	1020	592	84	624	443	55	1.14	1.00	1.30	0.045	0.029
PFAS	pos8110739	1659	85	0	1122	37	0	0.64	0.43	0.96	0.03	1630	64	2	1068	51	1	1.18	0.81	1.71	0.384	0.034
Pyrimidine metabolism
CTPS	rs6675122	1030	611	106	615	475	69	1.18	1.04	1.33	0.009	960	619	118	624	442	56	0.98	0.86	1.11	0.706	0.034
CTPS	rs41268101	1121	521	92	677	402	61	1.16	1.02	1.32	0.022	1026	568	88	670	387	45	0.95	0.83	1.09	0.441	0.034
DPYD	rs667565	671	810	266	378	573	207	1.18	1.06	1.31	0.003	614	814	268	439	508	175	0.92	0.82	1.03	0.127	0.001
DPYD	rs4520446	501	879	363	318	566	274	1.09	0.98	1.21	0.135	464	824	397	331	555	234	0.90	0.81	1.00	0.057	0.016
DPYD	rs7522938	752	745	216	440	540	164	1.15	1.03	1.29	0.011	712	760	208	498	469	145	0.96	0.86	1.08	0.482	0.019
DPYD	rs2811182	562	887	297	413	538	208	0.96	0.86	1.07	0.43	617	784	296	360	553	209	1.12	1.00	1.25	0.041	0.042
DPYS	rs1962267	550	872	325	417	555	187	0.87	0.78	0.97	0.014	586	802	309	378	535	209	1.02	0.92	1.14	0.689	0.033
DPYS	rs2853160	489	889	369	303	580	276	1.08	0.97	1.20	0.158	460	839	398	317	569	236	0.93	0.83	1.03	0.169	0.036
DPYS	rs17834440	1295	427	25	908	239	12	0.82	0.69	0.97	0.018	1318	359	20	853	250	19	1.11	0.94	1.31	0.223	0.008
DPYS	rs2853178	859	750	138	601	475	83	0.93	0.83	1.05	0.242	889	680	128	571	448	103	1.10	0.97	1.24	0.142	0.049
DPYS	rs13263121	751	782	212	530	492	136	0.93	0.84	1.04	0.227	764	751	181	480	496	145	1.13	1.01	1.27	0.034	0.02
DPYS	rs1319371	1053	613	81	672	422	65	1.10	0.97	1.25	0.157	1011	592	94	683	387	52	0.90	0.79	1.02	0.106	0.03
DPYS	rs35450967	1034	626	87	654	435	70	1.11	0.98	1.26	0.1	982	616	99	671	397	54	0.88	0.77	1.01	0.061	0.012
PPAT	rs13135046	516	857	374	362	579	216	0.91	0.82	1.01	0.079	519	837	338	314	569	239	1.08	0.96	1.20	0.198	0.023
TYMS	rs2298582	1336	393	18	914	234	11	0.86	0.73	1.02	0.09	1356	327	14	864	235	22	1.21	1.02	1.44	0.027	0.006

^a)

Adjusted for age (continuous), study stratum and the first five eigenvalues from principal components analysis. SNP effect was determined using a log-additive logistic regression model.

^b)

Allele counts: AA=homozygous wildtype allele carriers; AB=heterozygous allele carriers; BB=homozygous variant allele carriers.

^c)

P-value for interaction.

^d)

SNP is located 5′ downstream of gene; all other SNPs are located in introns; ‘pos’ SNPs are novel and identified by chromosomal position.