Skip to main content
. 2014 Jul 9;6(9):1124–1132. doi: 10.15252/emmm.201404170

Figure 3. Hdac3 is expressed in human atherosclerotic plaque macrophages, especially in inflammatory regions.

Figure 3

  • A Microarray which was performed on RNA from ruptured and paired stable control segments (n = 20, respectively). HDAC3 (P = 0.00007), HDAC5 (P = 0.00005), HDAC7b (P = 0.0003), HDAC9 (P = 0.00004).
  • B Correlation of HDAC3 with macrophage marker CD68 in gene expression data from human atherosclerotic lesions (n = 40). Statistical analysis was performed with Pearson's correlation test.
  • C, D Hdac3 is present in CD68+ areas in plaque shoulder (n = 21) and cap (n = 14) regions, while CD68+ areas in the adventitia (n = 12) showed negligible co-localization with Hdac3. Error bars indicate SEM. P = 0.0001 compared to both shoulder and cap regions with 1-way ANOVA.
  • E Correlation of HDAC3 with the pro-inflammatory marker CD86.
  • F Correlation of HDAC3 with the pro-fibrotic gene TGFB1.