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. 2014 Jul 28;6(9):1142–1160. doi: 10.15252/emmm.201303671

Figure 4. TFEB ameliorates neuronal loss and neuroinflammation.

Figure 4

  • A Immunofluorescence staining of untreated or TFEB-treated (+TFEB) hippocampus of wild-type (WT) and rTg4510 (Tau) mice using the anti-NeuN antibody. Scale bar: 1000 μm.
  • B Enlarged view of the bracketed areas in A. Scale bar: 50 μm.
  • C Unbiased stereological quantification of NeuN-positive neurons in area CA1 of wild-type (WT) or Tau transgenic mice injected with GFP or TFEB. n = 4 sections/mice, 5 mice/group. Student's t-test, **P = 0.0063.
  • D Wet brain weight measurement of WT or Tau mice with (+TFEB) or without TFEB injection. n = 14 mice/group. ***P < 0.001 (2 way ANOVA with Bonferroni post hoc). Each bar represents average ± s.e.m.
  • E, F Representative immunofluorescence images of cortex (CTX) or hippocampus (HPC) of untreated or TFEB-treated (+TFEB) rTg4510 (Tau) mice stained with anti-Iba1 (E) or anti-GFAP (F) antibodies antibody. Scale bar in E: 200 μm; in F. 400 μm.