Table 1.
List of some RNAi inactivations that lead to suppression of the accumulation of SQST-1::GFP aggregates in the intestine in rpl-43 mutants
| Process | Sequence name | Gene name | Brief description of gene product |
|---|---|---|---|
| Signaling | F54C8.5 | rheb-1 | Orthologous to the mammalian Rheb and Rheb1 GTPases |
| Signaling | R13F6.9 | sma-3 | A Smad protein |
| Signaling | R12B2.1 | sma-4 | A Smad protein |
| Signaling | F02A9.6 | glp-1 | N-glycosylated transmembrane protein |
| Signaling | T20F10.1 | wts-1 | Warts/lats-like serine threonine kinase |
| Signaling | F42G8.8 | Serine/threonine-protein phosphatase PP1 | |
| Signaling | C36B1.8 | gls-1 | Transducer of the stress-activated PKC1-MPK1 signaling pathway |
| Signaling | Y54E10BL.6 | mek-2 | Mitogen-activated protein kinase kinase |
| Protein turnover | F23F12.6 | rpt-3 | An AAA ATPase subunit of the 19S regulatory particle of the 26S proteasome |
| Protein turnover | F19B6.2 | ufd-1 | Protein involved in the recognition of polyubiquitinated proteins |
| Protein turnover | F59E12.5 | npl-4.2 | Ubiquitin-binding protein involved in protein degradation |
| Protein turnover | C06A1.1 | cdc-48.1 | An AAA ATPase homologous to yeast Cdc48 and mammalian p97/VCP |
| Transcription | F47D12.4 | hmg-1.2 | HMG box-containing protein |
| Transcription | F31E3.1 | ceh-20 | Homeobox family member |
| Transcription | C01B7.1 | ztf-12 | Zinc finger transcription factor family |
| Transcription | R06C7.7 | lin-61 | Polycomb group protein SCM/L(3)MBT |
| Transcription | C32F10.2 | lin-35 | The Caenorhabditis elegans retinoblastoma protein (Rb) ortholog |
| Transcription | JC8.6 | lin-54 | Metallothionein-like protein |
| Transcription | F52C12.5 | elt-6 | GATA-4/5/6 transcription factor |
| Transcription | F44C4.2 | nhr-37 | Nuclear hormone receptor |
| Transcription | D2021.1 | utx-1 | General transcriptional co-repressor |
| Transcription | C33D3.1 | elt-2 | GATA-type transcription factor |
| Protein trafficking | C07G1.5 | hgrs-1 | Membrane trafficking and cell signaling protein HRS |
| Protein trafficking | ZK652.2 | tomm-7 | Translocase of outer mitochondrial membrane complex |
| Protein trafficking | E04A4.5 | Mitochondrial import inner membrane translocase | |
| Protein trafficking | F35H10.4 | vha-5 | Subunit a of the vacuolar H + -ATPase V0 sector |
| Protein trafficking | CD4.4 | vps-37 | A member of the endosomal sorting ESCRT-I complex |
| Metabolism | F54D8.3 | alh-1 | Aldehyde dehydrogenase |
| Metabolism | C28H8.11 | Tryptophan 2,3-dioxygenase | |
| Metabolism | F37E3.1 | ncbp-1 | Nuclear cap-binding protein complex |
| Metabolism | K04E7.2 | pep-2 | A low-affinity/high-capacity oligopeptide transporter |