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. 2014 Apr 7;15(6):714–722. doi: 10.1002/embr.201338181

Figure 3. Hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance in BIG3-knockout (BKO) mice.

Figure 3

A, B Postprandial glycemia (A) and insulinemia (B) in BKO and control mice. Data are presented as mean ± s.e.m. N = 14 per group, *P < 0.05, **P < 0.01, t-test.

C, D Serum proinsulin (C) and proinsulin-to-insulin ratio (D) at rest, fast, and refed conditions. Data are presented as mean ± s.e.m. N = 8 per group, t-test.

E  Glucose levels of oral glucose tolerance tests (OGTT) for BKO and control mice. Data are presented as mean ± s.e.m. N = 12 per group, *P < 0.05, t-test.

F Insulin response during OGTT for BKO and control mice. Data are presented as mean ± s.e.m. N = 10 per group, *P < 0.05, t-test.

G Postprandial glycemia time course after fasting-refeeding. Data are presented as mean ± s.e.m. N = 10 per group, *P < 0.05, **P < 0.01, t-test.

H–K Hyperinsulinemic-euglycemic clamp measurements of glucose infusion rate (H), hepatic glucose production (HGP, I), overall glucose uptake (J), and muscle/adipose glucose uptake (K). BAT: brown adipose tissue; WAT: white adipose tissue; SOL: soleus muscle; EDL: extensor digitorum longus muscle. Data are presented as mean ± s.e.m. N = 3 per group, *P < 0.05, **P < 0.01, t-test.