Figure 5.

Effect of IVF on the adult liver metabolome. A, Categorical distribution of the 32 metabolites significantly altered in IVF males from controls. B, Heat map depicting fold-change in metabolite concentration between IVF and control metabolite values in male liver samples, including z-distribution of individual control (blue) and IVF (red) values relative to their respective population means. C, MSEA summary of Bonferroni-corrected pathways associated with the metabolite changes. D–F, Same as A–C but for the 31 metabolites altered in female IVF liver samples. G and H, Venn diagrams showing overlap in altered metabolites (G and purple symbols) and MSEA-identified pathways (H and green symbols) between male and female IVF cohorts.