Table 3.
Characteristics of isolated resistance arteries excised from the epididymal white adipose tissue of young and old B6D2F1 mice
| Young | Old | |
|---|---|---|
| n | 8 | 7 |
| Lumen diameter (μm) | 207 ± 12 | 182 ± 19 |
| ACh | ||
| Pre-constriction (%) | 36 ± 6 | 28 ± 4 |
| Max dilation (%) | 97 ± 1 | 75 ± 12* |
| EC50 [log M] | −8.0 ± 0.4 | −6.5 ± 0.4* |
| ACh + l-NAME | ||
| Pre-constriction (%) | 59 ± 6† | 47 ± 11 |
| Max dilation (%) | 26 ± 4† | 15 ± 4† |
| EC50 [log M] | −7.1 ± 0.2 | −7.0 ± 0.7 |
P < 0.05, means ± s.e.m. Abbreviations: ACh, acetylcholine; EC50, sensitivity assessed by determining the dose ACh eliciting half of the maximal dilator response; l-NAME, NG-nitro-l-arginine methyl ester.
*
Denotes difference from young.
†
Denotes difference from ACh alone.