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Simulated accumbal dopamine response to TC-7020 and nicotine starting from a baseline [dopamine] of 337 nM. The compounds were administered with a τin of 10 s and τout of 200 s. Simulations of the desensitization model with its standard parameters, except for a weaker connection weight from the GABAergic to dopaminergic neurons (1 vs 1.5) and a different cholinergic tone at α7 versus α4β2 NNRs (33 vs 3 μM). The red trace plots the response after pretreatment with PNU-120596.
