. 2014 Aug 22;5(10):1032–1040. doi: 10.1021/cn500126t

Table 1. Parameters of the Hill Functions Used to Model the Receptors’ Activation and Desensitization Gates.

α7	TC-7020	nicotine	acetylcholine
EC₅₀^a (μM)	0.03	13^d	68^d
n_Ha^b	1.73	1.73	1.73
DC₅₀^a (μM)	0.002	1.3
n_Hs^b	2	2
E_max^c (%)	30	80	100

α4β2	nicotine	acetylcholine
EC₅₀^a (μM)	0.23^e	30
n_Ha^b	1.05	1.05
DC₅₀^a (μM)	0.061
n_Hs^b	0.5
E_max^c (%)	80^f	100

EC₅₀ (DC₅₀), concentration of half-maximal activation (desensitization).

n_Ha (n_Hs), Hill exponent of activation (desensitization).

E_max, efficacy.

See ref (72).

See ref (68).

See ref (73).