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. 2014 Aug 20;5(10):1020–1031. doi: 10.1021/cn5000953

Figure 1.

Figure 1

(A) Illustration of the compounds (i) heterocycle, (ii) AMW610, (iii) AST3-88, and (iv) AMW6103. The stereochemistry of the thioether ring is represented by an asterisk (*). Compounds AST3-88 and AMW610 contain l-Cys, and compound AMW6103 contains a d-Cys at this position. The side chain of His is depicted in green, DPhe in orange, Arg in blue, the heterocycle moiety in pink, and the disulfide bridge is circled in yellow. (B) Amino acid sequences of key endogenous and synthetic melanocortin peptides.