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Rat serum stability profiles of the peptides AST789-13, α-MSH, and AST3-88. Relative peptide concentrations are based on mass spec ion counts. AST789-13 completely degraded in less than 2 h. Endogenous linear peptide α-MSH rapidly degraded within 6 h with only ∼1% intact peptide remaining at the 24 h point. Compound AST3-88, with the engineered backbone, degraded slowly in rat serum with ∼40% remaining at 6 h, and ∼12% was detected by MS at the 24 h time point.
