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Mutations K166Q and S188T can lead to antigenic drift. (A) Amino acids neighboring mutation K166Q; (B) amino acids neighboring mutation K166Q.
Notes: Wild-type amino acids are shown in pink; mutations are shown in green. Potential interactions are shown as a dashed magenta line. Positions 166 and 188 are located in antigenic sites Sa and Sb, respectively, and are exposed to the solvent.
