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. 2014 Oct 8;9(1):560. doi: 10.1186/1556-276X-9-560

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Copyright © 2014 Yi et al.; licensee Springer.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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In vivo fluorescence imaging and in vivo anticancer effect of the hybrid PLA NPs/MMC-SPC. (A)In vivo fluorescence imaging of H₂₂ tumor-bearing mice after intravenous injection of the DiR-PLA NPs/MMC-SPC at 1, 3, and 12 h post-injection. (B)Ex vivo fluorescence imaging of H₂₂ tumor-bearing mice after intravenous injection of the DiR-PLA NPs/MMC-SPC at 12 h post-injection (Li, liver; S, spleen; K, kidney; H, heart; Lu, lung; T, tumor). (C) The change of tumor volumes of H₂₂ tumor-bearing mice treated with PBS, PLA NPs/SPC, PLA NPs/MMC-SPC, and MMC. (D) The change of body weights of H₂₂ tumor-bearing mice treated with 0.9% NaCl, PLA NPs/SPC, PLA NPs/MMC-SPC, and MMC.