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. 2014 Oct 15;9(10):e85556. doi: 10.1371/journal.pone.0085556

Table 2. Subgroup analysis of the included epidemiological studies.

Subgroup NO. of studies Weight Summary OR (95%CI) Q test (p) I2
PCB-153
Background exposure 10 76.6% 1.57(1.13–2.19) 0.0004 65%
Specific exposure 3 23.4% - 0.05 66%
Total 13 100% 1.52(1.19–1.94) 0.0002 64%
Perspective study 4 23.5% 1.05(0.78–1.40) 0.60 0%
Cross-sectional study 9 76.5% 1.69(1.24–2.31) <0.0001 72%
Total 13 100% 1.50(1.18–1.92) 0.0002 63%
General population 10 74.7% 1.69(1.23–2.33) <0.0001 71%
Women 3 25.3% 1.11(0.85–1.46) 0.41 0%
Total 13 100% 1.52(1.19–1.94) 0.0002 64%
Serum 6 38.8% 1.36(0.95–1.95) 0.002 74%
Serum lipid 10 61.2% 1.62(1.18–2.24) 0.0002 67%
Total 13 100% 1.44(1.18–1.76) <0.00001 74%
PCBs
Background exposure 4 31.6% 1.74(1.22–2.48)a 0.22 30%
Specific exposure 7 68.4% 2.39(1.52–3.77) 0.001 67%
Total 11 100% 2.14(1.53–2.99) 0.002 59%
Case-control study 2 10.9% 2.83(1.18–6.81)a 0.14 55%
Cross-sectional study 8 89.1% 2.28(1.55–3.34) 0.001 66%
Total 10 100% 2.36(1.64–3.41) 0.0008 64%
General population 9 80.4% 2.18(1.50–3.16) 0.006 59%
Women 2 19.6% 1.88(0.56–6.26) 0.02 74%
Total 11 100% 2.19(1.54–3.13) 0.001 62%
Serum 6 48.3% 2.31(1.71–3.11)a 0.36 8%
Serum lipid 7 51.7% 1.91(1.20–3.04) 0.009 62%
Total 11 100% 2.24(1.62–3.10) 0.001 58%
p,p′-DDE
Background exposure 12 45.2% 1.39(1.16–1.67)a 0.18 25%
Specific exposure 6 54.8% 1.20(1.01–1.43) 0.001 75%
Total 18 100% 1.33(1.15–1.54) 0.0007 56%
Perspective study 4 14.7% 1.16(0.87–1.55)a 0.64 0%
Cross-sectional study 13 85.3% 1.33(1.13–1.56) 0.0006 62%
Total 17 100% 1.29(1.12–1.48) 0.003 52%
General population 15 72.9% 1.41(1.17–1.71) 0.0008 59%
Women 3 27.1% 1.27(1.10–1.46)a 0.79 0%
Total 18 100% 1.33(1.15–1.54) 0.0007 56%
Serum 8 24.4% 2.22(1.32–3.73) 0.005 66%
Serum lipid 14 75.6% 1.34(1.14–1.57) 0.001 58%
Total 18 100% 1.45(1.24–1.70) <0.0001 62%
a

Based on fixed model, others based on random model.