Table 2. Subgroup analysis of the included epidemiological studies.
Subgroup | NO. of studies | Weight | Summary OR (95%CI) | Q test (p) | I2 |
PCB-153 | |||||
Background exposure | 10 | 76.6% | 1.57(1.13–2.19) | 0.0004 | 65% |
Specific exposure | 3 | 23.4% | - | 0.05 | 66% |
Total | 13 | 100% | 1.52(1.19–1.94) | 0.0002 | 64% |
Perspective study | 4 | 23.5% | 1.05(0.78–1.40) | 0.60 | 0% |
Cross-sectional study | 9 | 76.5% | 1.69(1.24–2.31) | <0.0001 | 72% |
Total | 13 | 100% | 1.50(1.18–1.92) | 0.0002 | 63% |
General population | 10 | 74.7% | 1.69(1.23–2.33) | <0.0001 | 71% |
Women | 3 | 25.3% | 1.11(0.85–1.46) | 0.41 | 0% |
Total | 13 | 100% | 1.52(1.19–1.94) | 0.0002 | 64% |
Serum | 6 | 38.8% | 1.36(0.95–1.95) | 0.002 | 74% |
Serum lipid | 10 | 61.2% | 1.62(1.18–2.24) | 0.0002 | 67% |
Total | 13 | 100% | 1.44(1.18–1.76) | <0.00001 | 74% |
PCBs | |||||
Background exposure | 4 | 31.6% | 1.74(1.22–2.48)a | 0.22 | 30% |
Specific exposure | 7 | 68.4% | 2.39(1.52–3.77) | 0.001 | 67% |
Total | 11 | 100% | 2.14(1.53–2.99) | 0.002 | 59% |
Case-control study | 2 | 10.9% | 2.83(1.18–6.81)a | 0.14 | 55% |
Cross-sectional study | 8 | 89.1% | 2.28(1.55–3.34) | 0.001 | 66% |
Total | 10 | 100% | 2.36(1.64–3.41) | 0.0008 | 64% |
General population | 9 | 80.4% | 2.18(1.50–3.16) | 0.006 | 59% |
Women | 2 | 19.6% | 1.88(0.56–6.26) | 0.02 | 74% |
Total | 11 | 100% | 2.19(1.54–3.13) | 0.001 | 62% |
Serum | 6 | 48.3% | 2.31(1.71–3.11)a | 0.36 | 8% |
Serum lipid | 7 | 51.7% | 1.91(1.20–3.04) | 0.009 | 62% |
Total | 11 | 100% | 2.24(1.62–3.10) | 0.001 | 58% |
p,p′-DDE | |||||
Background exposure | 12 | 45.2% | 1.39(1.16–1.67)a | 0.18 | 25% |
Specific exposure | 6 | 54.8% | 1.20(1.01–1.43) | 0.001 | 75% |
Total | 18 | 100% | 1.33(1.15–1.54) | 0.0007 | 56% |
Perspective study | 4 | 14.7% | 1.16(0.87–1.55)a | 0.64 | 0% |
Cross-sectional study | 13 | 85.3% | 1.33(1.13–1.56) | 0.0006 | 62% |
Total | 17 | 100% | 1.29(1.12–1.48) | 0.003 | 52% |
General population | 15 | 72.9% | 1.41(1.17–1.71) | 0.0008 | 59% |
Women | 3 | 27.1% | 1.27(1.10–1.46)a | 0.79 | 0% |
Total | 18 | 100% | 1.33(1.15–1.54) | 0.0007 | 56% |
Serum | 8 | 24.4% | 2.22(1.32–3.73) | 0.005 | 66% |
Serum lipid | 14 | 75.6% | 1.34(1.14–1.57) | 0.001 | 58% |
Total | 18 | 100% | 1.45(1.24–1.70) | <0.0001 | 62% |
Based on fixed model, others based on random model.