Table 2. Linkage of trehalose-6-mycolate, phosphatidylinositol and the D-series resolvin metabolite(s) in plasma of patients without or with MDR-TB.
Metabolite feature | Non-MDR-TB patientsa b | MDR-TB patientsc | Household contactsd |
Trehalose-6-mycolate | 13/14 | 1/3 | 1/17 |
Phosphatidylinositol (PI) | 14/14 | 1/3 | 1/17 |
D-series resolvin | 12/14 | 2/3 | 2/17 |
In all 13 non-MDR-TB patients with detectable trehalose-6-mycolate metabolite in plasma, the phosphatidylinositol metabolite was also detected.
In all 12 non-MDR-TB patients with the D-series resolvin(s) metabolite detected in plasma, the trehalose-6-mycolate and PI metabolites were concomitantly detected.
One of 3 patients with MDR-TB demonstrated the D-series resolvin(s), trehalose-6-mycolate and PI metabolites in plasma.
One of the 17 smear-negative household contacts demonstrated both trehalose-6-mycolate and the PI metabolites in plasma, but these metabolites were undetectable the other household contacts.
The D-series resolvin metabolite(s) was detected in plasma of 2 other household contacts.