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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Clin Cancer Res. 2013 Dec 2;20(4):912–925. doi: 10.1158/1078-0432.CCR-13-2281

Figure 6. JQ1 prolongs survival of xenograft models of Group 3 medulloblastoma.

Figure 6

A, Kaplan-Meier curves of mice with intracranial xenograft injections of MB002 treated with JQ1 or vehicle.

B, Rate of tumor growth in NSG mice with orthotopic MB002 xenografts following treatment with JQ1 as monitored by bioilluminescence detection

C, qPCR of MYC mRNA levels (normalized to β-actin) in cerebellar xenografts of MB002 following treatment with either vehicle control or JQ1. Values represent mean ± SD of six replicate measurements.

D, Representative images of Ki67 staining of MB002 xenografts treated with vehicle control and JQ1 (Top panel). % Ki67 positivity in tumors from mice treated with either vehicle control (n=2) or JQ1(n=3). Values represent mean ± SD of three replicate measurements for each animal.