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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Am J Reprod Immunol. 2010 May 26;64(4):255–264. doi: 10.1111/j.1600-0897.2010.00860.x

Fig. 2.

Fig. 2

Schematic diagram of the functional domains of Env glycoproteins proposed to be involved in placental morphogenesis compared to a typical exogenous betaretroviral Env. ERV3 codes for a truncated Env in humans, with 1% of the population having a stop codon within the amino terminus of the SU region. Syncytin 2 (human) and syncytin-B (mouse) contain all the hallmarks of intact and functional Env proteins, including the leader peptide, furin cleavage site, fusion peptide, immunosuppressive domain, membrane-spanning domain, and a cytoplasmic tail.