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. 2014 Oct 15;9(10):e109948. doi: 10.1371/journal.pone.0109948

Figure 2. Impaired 5C-CPT performance during initial hours of EtOH abstinence.

Figure 2

In a test performed 3 h into EtOH abstinence using familiar task conditions EtOH-exposed rats (n = 16) failed to respond to nearly half of the presented trials (panel A), took longer to elicit correct responses in Go trials (panel D), exhibited diminished discrimination between Go and NoGo trials (panel G) and a diminished tendency to respond (panel H) as compared with EtOH-naïve CON animals (n = 17), suggesting an impairment in the ability to perform the task. The lack of group differences in the percentage of correct responses in Go trials (panel B), false alarm latency (panel E) or the latency to retrieve the food rewards (F) suggests an equal capacity to “solve” the 5C-CPT task and a similar motivation to do so. There were no group differences in motor impulsivity (premature responses, I) or behavioral restraint (false alarms, panel C) at this abstinence time. Significant group effects denoted by * p<0.05, ** p<0.01, *** p<0.001 as determined by 1-way ANOVA.