Table 2.

Antiproliferative Activity of Biphenyl Triazole Analogues 5^a

R (5, IC50, μM)	SKBr3b	MCF-7b	MDA- MB-468LNc	MDA1986c	JMARc	PC3- MM2d	LNCaPd
Ph (5a)	1.14±0.10a	1.44±0.18a	0.83±0.16	1.30±0.09	2.20±0.24	4.26±5.59	3.89±1.09
Bn (5b)	0.17±0.02	0.50±0.02	0.34±0.07	0.28±0.10	0.50±0.06	0.55±0.46	0.65±0.54
CH2Bn (5c)	0.19±0.02	0.38±0.10	0.36±0.04	0.10±0.23	0.58±0.46	0.83±0.34	0.43±0.22
4-ClBn (5d)	0.32±0.10	0.44±0.04	0.74±0.19	1.30±0.37	2.30±0.82	0.66±0.21	1.59±0.78
4-BrBn (5e)	0.49±0.03	0.56±0.04	2.80±0.61	3.10±0.87	7.80	19.9±27.9	0.54±0.12
4-MeBn (5f)	0.17±0.03	0.12±0.01	0.41±0.26	0.36±0.05	0.42±0.07	0.36±0.04	0.20±0.04
4-MeOBn (5g)	0.16±0.02	0.27±0.06	0.17	0.48±0.09	0.61±0.09	0.44±0.19	0.24±0.07
4-t-BuBn (5h)	3.72±0.68	10.48±0.40	2.61±0.76	2.34±1.81	3.49±2.05	>100	1.01±1.39
4-NO2 (5i)	0.45±0.04	0.55±0.01	0.56±0.25	0.19±0.17	0.21±0.35	1.03±0.16	0.60±0.34
4-FBn (5j)	0.72±0.18	1.04±0.08	1.09±0.23	0.93±0.34	1.39±0.52	2.81±1.82	1.64±0.97
3-ClBn (5k)	0.39±0.01	0.34±0.02	0.17±0.02	0.17±0.12	0.27±0.04	0.35±0.14	0.12±0.10
3-MeOBn (5l)	0.32±0.02	0.16±0.02	0.19±0.05	0.28±0.09	0.21±0.12	0.55±0.37	0.16
2-ClBn (5m)	0.34±0.04	0.38±0.03	0.22±0.03	0.81±0.05	0.65	1.04±0.51	0.61±0.34
2-Cl,4-MeBn (5n)	0.16±0.01	0.20±0.05	0.15±0.02	0.15±0.06	0.43±0.25	0.35±0.12	0.05±0.04
CH2C6H13 (5o)	0.20±0.02	0.31±0.04	0.24±0.06	0.38±0.14	0.26±0.45	5.12±6.54	0.48±0.68

^aValues represent mean ± standard deviation for at least two separate experiments performed in triplicate.

^bCellular activities were determined with MTS/PMS cell viability assay.

^cCellular activities were determined with Promega CellTiter-Glo (CTG) luminescent assay.

^dCellular activities were determined with Sulforhodamine B Assay.