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Synthetic route to aminostrylpyridine moieties. Reagents and conditions: (a) K2CO3, DMF, 1-iodohexane (2a) or 1-iodo-dodecane (2b), (b) POCl3, DMF, (c) 3-bromo-4-methylpyridine, LDA, Et2O, (d) 3N-HCl, dioxane, 60 °C, (e) ethylacrylate, PPh3, Pd(OAc)2, TEA, DMF, 130 °C, (f) NaOH, H2O/EtOH/i-PrOH.
