Table 1. Potential mediators of p53 regulation of invadosomes formation and cell invasion.
| Protein sub‐groups | Nodes with connections to both p53 and invadosomes | Interactions with p53* | Effects of nodes on invadosome formation and/or cell invasion | ||
|---|---|---|---|---|---|
| Transcriptional regulation by p53 | Non‐transcriptional regualtion by p53 | Effects of nodes on p53 expression and/or activity | |||
| ECM proteins and MMPs | Fibronectin | ↓(48) | ↓(47) | NA | ↑ (42, 45, 46) |
| MT1‐MMP | ↓ (55) | NA | NA | ↑ (50, 53, 54) | |
| MMP‐2 | ↓ or ↑ (55) | NA | NA | ↑ (49) | |
| Focal adhesion and associated proteins | Integrin | ↓ (63,64) | ↑ by mutp53 (65,66) | ↓ (41,67) | ↑ (56,59‐62) |
| Supervillin | NA | NA | ↓ (71) | ↑(70); ↓ (69) | |
| FAK | ↓ (77) | NA | ↓ (78, 79) | ↑ (73, 74); ↓ (75, 76) |
|
| Calpain | NA | NA | ↓ (90‐92) | ↑ (89); ↓(85‐ 87) |
|
| Growth factors and receptors | EGFR | ↓ (16) | NA | ↓ (95) | ↑ (5) |
| MET | ↓ (16, 98) | NA | ↓ (98) | ↑ (5) | |
| PDGF | ↓ (99) | NA | ↓ (100, 101) | ↑ (28) | |
| TGF‐β | NA | NA | ↓ (103) | ↑ (102) | |
| Signaling molecules | Src | NA | ↓ (19, 20) | ↓ (19, 20, 21) | ↑ (6,20,21,28) |
| PTEN | ↑ (16) | NA | NA | ↓ (20, 34) | |
| PKCε | NA | ↓ (28) | NA | ↑ (28) | |
| STAT3 | NA | ↓(40) | ↓ (38,39) | ↑ (20) | |
| Rho GTPases and regulators of actin polymerization | Cdc42 | NA | ↓(113) | NA | ↑ (107,109‐111); ↓(112) |
| RhoA | NA | ↓ (3, 123, 126); ↑ by mutp53 (124) | NA | ↑ (110, 118, 119, 122); ↓ (120‐122) | |
| RhoC | ↑ (108,125,128) | ↑ (125) | NA | ↓ (127) | |
| Rac | NA | ↓ (132, 133) | NA | ↑ (129,130, 131); ↓ (122,131) | |
| RhoE (Rn3) | ↑ (134) | ↑(134) | NA | ↑ (135) | |
| Caldesmon | ↑ (17, 21, 24) | NA | NA | ↓ (25,26) | |
| Fascin | NA | ↓ (28) | NA | ↑ (30) | |
| miRNAs | miRNA‐143/145 | ↑ (28) | ↑(29) | NA | ↓ (28) |
Protein nodes are listed as functional sub-groups that have been shown to have connections to both p53 and invadosomes. They represent potential mediators of p53-dependent downregulation of cell invasion via podosome and invadopodia formation in cancer and vascular smooth muscle cells. *Listed here are references (in brackets) that have provided evidence for three different modes of interaction between protein nodes and p53: (1) proteins as transcriptional targets of p53; (2) post-transcriptional protein expression and activity regulated by p53; and (3) effect of proteins on p53 expression and stability, providing a potential feedback loop. NA, evidence not available to my knowledge; ↓, downregulation; ↑, upregulation.