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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Apoptosis. 2014 Nov;19(11):1616–1626. doi: 10.1007/s10495-014-1029-5

Fig. 1. DAPT synergizes with VCR in killing GSI-resistant T-ALL.

Fig. 1

GSI-resistant NOTCH1 mutant T-ALL lines (a, Jurkat; b, CEM; c P12, 4X104 cells/24well, Dotted lines) were treated with the indicated doses of chemodrugs (VCR, Vincristine; Ara C, Cytarabine; ASP, Asparaginase; MTX, Methotrexate) in the presence of DAPT (10 μM) or DMSO for 48 h. At the end of the culture, the viable cell numbers were enumerated by counting the cells with intact morphology after staining with trypan blue. All results are presented as mean ± SD of triplicate assays. The statistical significance of differences was determined by ANOVA test; *, p < 0.05; **, p < 0.01; ***, p< 0.001