Table 2.
Adjusted* risk ratios (95% confidence intervals) for the association of pre-diabetes and diabetes with 6-year incident elevated (≥ 14 ng/L) highly sensitive cardiac troponin T (hs-cTnT) at visit 4 (1996-1998) according to diagnostic categories of pre-diabetes and diabetes defined by hemoglobin A1c (HbA1c) and stratified by baseline category of hs-cTnT at visit 2 (1990-1992)
| Baseline (visit 2, 1990-1992) Troponin Group (N = 9,331) | ||||||
|---|---|---|---|---|---|---|
| < 5 ng/L (N = 6,438) | 5 – 8 ng/L (N = 2,155) | 9 – 13 ng/L (N = 738) | ||||
| n cases /Total N | RR (95%CI) | n/N | RR (95%CI) | n/N | RR (95%CI) | |
| HbA1c diagnostic criteria | ||||||
| < 5.7 % (no diabetes) | 42/4613 | 1 (reference) | 78/1326 | 1 (reference) | 94/394 | 1 (reference) |
| 5.7 – 6.4% (pre-diabetes) | 25/1389 | 2.00 (1.17-3.43) | 40/569 | 1.18 (0.77-1.80) | 51/214 | 0.98 (0.62-1.55) |
| Diabetes (≥ 6.5% or diagnosis) | 11/436 | 3.34 (1.60-6.98) | 27/260 | 2.31 (1.36-3.93) | 27/130 | 1.42 (0.78-2.60) |
| p-value for trend† | <0.001 | 0.006 | 0.375 | |||
Adjusted for age (years), race-center (whites-Washington County; whites-Minneapolis; blacks-Jackson; blacks-Forsyth County, whites-Forsyth County), sex (male or female), body mass index (kg/m2), C-reactive protein (mg/L), smoking (current; former; never), mean systolic blood pressure (mm Hg), LDL-cholesterol (mg/dL), HDL-cholesterol (mg/dL), triglycerides (mg/dL), estimated glomerular filtration rate (mL/min/1.73m2), current use of hypertension medication (yes or no), current lipid-lowering medication use (yes or no), alcohol use (current; former; never) and left ventricular hypertrophy (yes or no).
p-values for linear trend were obtained by numbering the categories 1 through 3 and including this categorical variable as a linear term in the model.