Table 1.
Up‐regulated and down‐regulated miRNAs in stage I SCC and AC tissues defined by deep sequencing.
| SCC | AC | ||||
|---|---|---|---|---|---|
| miRNAs | Fold‐change (tumor/normal) | p Value | miRNAs | Fold‐change (tumor/normal) | p Value |
| miR‐548a‐3p | 12.308824 | 0.00012743 | miR‐431‐5p | 6.317018 | 2.91617E‐06 |
| miR‐1291 | 8.060843 | 2.43E‐23 | miR‐323a‐3p | 5.698014 | 2.542E‐05 |
| miR‐205‐5p | 6.173350 | 1.56E‐15 | miR‐9‐3p | 5.518930 | 6.29421E‐05 |
| miR‐147b | 5.515700 | 1.20E‐07 | miR‐196a‐5p | 5.452727 | 9.32211E‐06 |
| miR‐183‐3p | 5.404806 | 4.68E‐06 | miR‐668 | 5.260027 | 0.000104731 |
| miR‐1269b | 5.401679 | 1.08E‐06 | miR‐376b‐3p | 5.118238 | 0.000128737 |
| miR‐944 | 5.342495 | 2.26E‐11 | miR‐182‐3p | 4.804702 | 0.000568362 |
| miR‐9‐5p | 5.304565 | 1.85E‐12 | miR‐4435 | 4.583124 | 0.000231087 |
| miR‐205‐3p | 4.829734 | 0.000325 | miR‐21‐5p | 4.485680 | 3.45658E‐05 |
| miR‐196a‐5p | 4.771010 | 9.80E‐10 | miR‐196a‐3p | 4.482990 | 9.99902E‐06 |
| miR‐577 | 4.687445 | 8.85E‐06 | miR‐1185‐1‐3p | 4.430215 | 0.000608887 |
| miR‐335‐3p | 4.500000 | 3.45E‐05 | miR‐431‐3p | 4.404831 | 0.000671589 |
| miR‐21‐5p | 4.480231 | 1.11E‐06 | miR‐1197 | 4.388206 | 0.000327892 |
| miR‐3609 | 4.463120 | 2.85E‐12 | miR‐323b‐3p | 4.369117 | 0.000691047 |
| miR‐1910 | 3.899553 | 7.82E‐05 | miR‐9‐5p | 4.366718 | 2.97523E‐05 |
| miR‐149‐5p | 3.842863 | 6.61E‐07 | miR‐487a | 4.332483 | 0.000695979 |
| miR‐873‐3p | 3.679904 | 3.11E‐05 | miR‐380‐3p | 4.303067 | 0.000425358 |
| miR‐758‐3p | 3.335272 | 0.000736 | miR‐577 | 4.005734 | 0.001037253 |
| miR‐301b | 3.309103 | 2.99E‐05 | miR‐410 | 3.966207 | 0.000198251 |
| miR‐708‐5p | 3.191239 | 5.37E‐06 | miR‐192‐5p | 2.789685 | 0.0001095 |
| miR‐31‐5p | 3.180813 | 1.36E‐05 | miR‐451a | −2.526477 | 0.001015833 |
| miR‐3676‐5p | 3.091173 | 0.00013327 | miR‐30a‐5p | −2.851723 | 1.60505E‐05 |
| miR‐31‐3p | 3.063404 | 0.00025179 | miR‐486‐3p | −3.131728 | 2.68134E‐05 |
| miR‐224‐5p | 2.979244 | 6.61E‐05 | miR‐490‐3p | −4.131157 | 0.000875453 |
| miR‐873‐5p | 2.923541 | 0.00189254 | miR‐30a‐5p | −4.453866 | 1.12345E‐05 |
| miR‐708‐3p | 2.865219 | 0.00017849 | miR‐30a‐3p | −4.516783 | 2.34568E‐05 |
| miR‐183‐5p | 2.793837 | 0.00015804 | miR‐486‐5p | −4.538656 | 1.12345E‐05 |
| miR‐409‐5p | 2.726459 | 0.00017722 | miR‐184 | −4.934109 | 4.68414E‐05 |
| miR‐449c‐5p | −2.502744 | 0.00114347 | |||
| miR‐3614‐5p | −2.530638 | 0.00047691 | |||
| miR‐223‐5p | −2.646799 | 7.93E‐05 | |||
| miR‐29b‐1‐5p | −2.868420 | 0.00031147 | |||
| miR‐30c‐2‐3p | −3.077404 | 3.17E‐05 | |||
| miR‐486‐3p | −3.338364 | 2.76E‐07 | |||
| miR‐138‐1‐3p | −3.407908 | 0.00095397 | |||
| miR‐30a‐3p | −4.656785 | 1.25E‐05 | |||
| miR‐486‐5p | −4.689655 | 1.23E‐07 | |||
| miR‐184 | −5.019975 | 3.00E‐07 | |||
| miR‐135a‐5p | −5.067272 | 5.70E‐06 | |||
| miR‐375 | −6.320925 | 4.08E‐18 | |||
SCC, squamous cell carcinoma; AC, adenocarcinoma.
Based on a 2.5‐fold change cut‐off value, 40 and 28 miRNAs show different level between stage I SCC or AC and normal tissues.
Based on a 4.5‐fold change cut‐off, 17 and 11 miRNAs (bold font) display dysregulation in either SCC or AC as shown in Figure 1C.