Table 2.

Subgroup meta-analyses of the association between MUC1 polymorphism rs4072037 and gastric cancer risk under the allele model

Comparison	No. of datasets	Case	Control	OR (95% CI)	Pfor OR	Pfor heterogeneity	I 2(%)	Model
Overall	12	10410	11437	0.70 (0.64,0.76)	<0.00001	0.04	47	Random
Anatomic location
Cardia gastric cancer	5	2362	7426	0.75(0.62,0.91)	0.004	0.04	63	Random
Non-cardia gastric caner	5	5161	7426	0.66 (0.58,0.74)	<0.00001	0.15	43	Fixed
Pathological subtype
Diffuse-type gastric cancer	6	1756	5191	0.65 (0.57,0.73)	<0.00001	0.29	19	Fixed
Intestinal-type gastric cancer	4	1727	3354	0.75 (0.66,0.83)	<0.00001	0.48	0	Fixed
Ethnicity
Asian	10	9826	10853	0.69 (0.63,0.75)	<0.00001	0.05	47	Random
Caucasion	2	584	584	0.76 (0.56,1.04)	0.08	0.07	70	Random
Sample size
>1000	6	8652	9614	0.73(0.69,0.78)	<0.00001	0.10	45	Fixed
≤1000	6	1758	1823	0.66 (0.59,0.75)	<0.00001	0.10	47	Fixed
Quality score
>7	5	6183	5742	0.73 (0.65,0.82)	<0.00001	0.27	23	Fixed
≤7	7	4227	5695	0.69 (0.64,0.75)	<0.00001	0.22	28	Fixed
Control source
Hospital-based	7	2683	3958	0.65 (0.59,0.72)	<0.00001	0.16	35	Fixed
Population-based	5	7727	7479	0.75 (0.70,0.81)	<0.00001	0.19	34	Fixed
Adjustment
Yes	9	9688	10612	0.69 (0.63,0.76)	<0.00001	0.04	51	Random
No	3	722	825	0.74 (0.63,0.86)	0.0001	0.13	51	Fixed
Statistical power
≥0.8	6	5595	8620	0.67(0.62, 0.72)	<0.00001	0.22	0.29	Fixed
<0.8	6	4815	4081	0.78(0.72,0.85)	<0.00001	0.27	0.22	Fixed

OR, odds ratio; CI, confidence interval.