Table 1.
Cell Line | IC50a, nM |
|||
---|---|---|---|---|
rGel | TAT-Gel | Fold Difference | ||
Cancer Cells | LS174T | 5130 ± 802 | 29.0 ± 15.0*** | 177 |
CT26 | 4190 ± 1120 | 72.2 ± 26.6** | 58 | |
U87 MG | 3100 ± 409 | 46 ± 13.7*** | 67 | |
9L | 4260 ± 856 | 57.8 ± 26.3** | 74 | |
HeLa | 4980 ± 920 | 66.4 ± 31.4*** | 75 | |
PC-3 | 3330 ± 761 | 63.4 ± 25.1** | 53 | |
Non Cancer Cells | MDCK | 3580 ± 846 | 53 ± 16.3** | 68 |
293 HEK | 4300 ± 1020 | 46.7 ± 14.0** | 92 |
IC50 values were calculated by nonlinear regression using Prism software (GraphPad). All experiments were performed with three different batches (N=3).
P < 0.001
P < 0.0001 by Student's t-test. (rGel: recombinant gelonin, TAT-Gel: recombinant TAT-gelonin fusion protein)