Table 2.

Urologic, and pelvic and non-pelvic pain symptoms¹ by flare status and duration among 64 participants with interstitial cystitis/bladder pain syndrome and/or chronic prostatitis/chronic pelvic pain syndrome, Washington University School of Medicine and the University of Alabama at Birmingham 2010-2013

	Non-Flare (n=64)	Flare duration				p-value2	p-value3
		Minutes-long (n=26)	Hours-long (n=24)	One day-long (n=16)	Multiple days-long (n=51)
Typical symptom severity (on a scale of 0-10, mean (range)):
Pelvic pain, pressure, or discomfort	4.3 (0 – 10)	5.2 (0 – 10)**	6.0 (2 – 10)****	7.0 (3 – 10)****	6.9 (2 – 10)****	<0.0001	0.0002
Urinary urgency	4.0 (0 – 10)	5.2 (0 – 10)****	4.3 (0 – 10)	5.6 (0 – 10)****	5.7 (0 – 10)****	<0.0001	0.21
Frequency	4.1 (0 – 10)	3.9 (0 – 10)	4.2 (0 – 10)	4.7 (0 – 9)	5.6 (0 – 10)****	0.0187	0.0054
Overall urologic or pelvic pain symptoms	4.3 (0 – 10)	5.5 (1 – 10)**	5.1 (1 – 9)	6.5 (2 – 10)***	6.2 (0 – 10)****	<0.0001	0.11
Overall non-urologic pain symptoms	4.2 (0 – 10)	3.1 (0 – 10)**	3.2 (0 – 10)*	3.2 (0 – 9)	4.0 (0 – 10)	0.045	0.087
Most bothersome symptom (%):
Pelvic pain, pressure, or discomfort4	65.6	74.7	77.1	78.1	76.7
Urologic symptoms5	17.2	7.4	9.3	6.4	10.7	0.0487	0.587
Other bothersome symptoms6	17.2	17.5	14.1	15.3	12.8

P-values for comparisons to non-flare levels:

^*0.05≤p<0.1;

^**0.01≤p<0.05;

^***0.001≤p<0.01;

^****p<0.001.

¹Means and percentages were calculated by generalized linear mixed models. P-values were calculated by generalized linear mixed models or conditional logistic regression, as appropriate.

²Comparing all flare to non-flare values.

³Assessing the linear trend in symptom severity by duration of flares.

⁴Includes pain, pressure, or discomfort in the pubic or bladder area; in the area between: their rectum and testicles (perineum, males only) or the vaginal area (females only);or during or after sexual activity.

⁵Includes urgency, frequency, nocturia, or sense of incomplete emptying.

⁶Includes the following symptoms reported by participants as “other bothersome symptoms” on the flare survey: pain during or after urination, urethral pain, pain at the tip of the penis, pain after ejaculation, pain/burning in the bladder, dripping with urination, fatigue, and back pain. “Other” responses were collected on the flare survey only; they were not collected in the parent Trans-Multidisciplinary Approaches to the Study of Chronic Pelvic Pain study.

⁷Comparing pelvic pain to all other symptoms.