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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Rev Med Virol. 2014 Apr 15;24(6):365–378. doi: 10.1002/rmv.1791

Figure 1.

Figure 1

Gammaherpesviruses inhibit MHC-I-restricted antigen presentation. vIRF1 interacts with the transcriptional coactivator p300 and thereby interferes with the MHC-I transcription. BGLF5, SOX and muSOX promote the degradation of host mRNAs and shutoff of MHC-I gene expression. EBNA1, LANA1 and mLANA escape being processed by the proteasome and inhibit their own translation. BNLF2a shuts down TAP-mediated import of antigenic peptides. mK3 directs immature MHC-I molecules to the cytosol and also degrades TAP and tapasin. BILF1, kK3 and kK5 trigger endocytosis of cell surface MHC-I molecules and promote their lysosomal degradation. vIL-10 downregulates TAP1 and bli/LMP2 (a subunit of proteasome) at the mRNA level.