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A schematic model summarizes the role of fezf2 in regulating Notch activity and NSC fate. A, In the DTel PVZ, heterogeneous cellular states are marked by a heterogeneous level of fezf2 expression, which further orchestrates a gradient Notch signaling activity among neighbors. B, At the molecular level, heterogeneous fezf2 levels control the levels of her4.1 in NSCs. This difference biases the directionality of Notch signaling and determines the fate outcomes.
