Table 3.
Diagnostic performance of ADNEX model when using different thresholds for total probability of malignancy (sum of probabilities of four subtypes of ovarian malignancy)
| Threshold for probability of malignancy* | Development data (n=3506) | Validation data (n=2403) | After updating on pooled data (n=5909) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | Sensitivity | Specificity | Diagnostic odds ratio | AUC | Sensitivity | Specificity | Diagnostic odds ratio | AUC | Sensitivity | Specificity | Diagnostic odds ratio | |||
| Not applicable | 0.954 (0.947 to 0.961) | — | — | — | 0.943 (0.934 to 0.952) | — | — | — | 0.950 (0.944 to 0.955) | — | — | — | ||
| 3% | — | 98.8 (97.9 to 99.4) | 52.3 (50.4 to 54.3) | 93.6 | — | 98.9 (98.0 to 99.4) | 46.6 (44.0 to 49.2) | 76.8 | — | 99.1 (98.6 to 99.5) | 43.4 (41.8 to 45.0) | 86.2 | ||
| 5% | — | 97.9 (96.8 to 98.7) | 65.4 (63.6 to 67.3) | 87.9 | — | 98.4 (97.4 to 99.1) | 59.4 (56.8 to 62.0) | 88.1 | — | 98.0 (97.3 to 98.6) | 61.1 (59.5 to 62.6) | 78.0 | ||
| 10% | — | 95.9 (94.4 to 97.1) | 75.5 (73.8 to 77.2) | 72.0 | — | 96.5 (95.2 to 97.6) | 71.3 (68.9 to 73.7) | 69.2 | — | 96.4 (95.4 to 97.2) | 73.2 (71.8 to 74.6) | 72.7 | ||
| 15% | — | 94.4 (92.8 to 95.8) | 81.0 (79.4 to 82.5) | 71.9 | — | 94.2 (92.5 to 95.6) | 77.2 (74.9 to 79.3) | 54.7 | — | 94.5 (93.4 to 95.5) | 78.7 (77.4 to 79.9) | 63.4 | ||
AUC=area under receiver operating characteristic curve.
Exact binomial 95% confidence intervals are reported in parentheses.
*Probability equal to or more than threshold indicates malignancy.