Table 5.

 Odds ratios for predictors in ADNEX model after it was updated on pooled dataset (n=5909)

Predictor	Borderline v benign	Stage I v benign	Stage II-IV v benign	Metastatic v benign
Patient age, per 10 years	1.05 (0.96 to 1.14)	1.19 (1.09 to 1.30)	1.67 (1.50 to 1.86)	1.40 (1.24 to 1.57)
Serum CA-125, per doubling*	1.12 (1.03 to 1.22)	1.22 (1.12 to 1.32)	2.15 (1.96 to 2.36)	1.32 (1.19 to 1.46)
Maximal diameter of lesion, per doubling *	1.45 (1.22 to 1.73)	2.40 (1.97 to 2.91)	1.54 (1.25 to 1.89)	1.57 (1.23 to 1.99)
Proportion solid tissue (%)†:
33 v 0 (no solid tissue)	5.44 (3.88 to 7.64)	12.8 (8.62 to 18.9)	16.9 (10.5 to 27.0)	7.09 (4.01 to 12.5)
67 v 33	1.55 (1.32 to 1.81)	3.49 (2.99 to 4.08)	4.74 (3.92 to 5.73)	4.25 (3.46 to 5.23)
100 v 67	0.44 (0.29 to 0.67)	0.95 (0.68 to 1.35)	1.33 (0.92 to 1.94)	2.55 (1.60 to 4.06)
>10 cyst locules	3.96 (2.65 to 5.90)	2.21 (1.42 to 3.43)	1.31 (0.74 to 2.32)	2.46 (1.33 to 4.56)
No of papillary projections	1.83 (1.65 to 2.03)	1.49 (1.33 to 1.68)	1.48 (1.28 to 1.71)	1.24 (1.01 to 1.52)
Acoustic shadows	0.13 (0.06 to 0.28)	0.15 (0.09 to 0.26)	0.09 (0.05 to 0.17)	0.08 (0.04 to 0.18)
Ascites	2.64 (1.44 to 4.86)	1.57 (0.93 to 2.67)	3.85 (2.39 to 6.20)	5.14 (3.00 to 8.79)
Oncology referral centre	2.59 (1.32 to 5.11)	1.57 (0.89 to 2.78)	1.58 (0.78 to 3.21)	2.25 (1.04 to 4.87)

*This variable is log transformed (log with base 2) such that the odds ratio represents the effect for each doubling of the value.

†This variable represents the maximal diameter of the largest solid component divided by the maximal diameter of the lesion (range 0% to 100%), with 0% indicating that there is no solid tissue and 100% indicating that the maximal diameter of the largest solid component equals the maximal diameter of the lesion. The variable has a quadratic effect in the model, hence we report odds ratios for 33% v 0%, 67% v 33%, and 100% v 67%.