Table 4.
Change from baseline for outcome measures at week 12
| Outcome measures | Immediate intervention group | Wait list control group | Mean difference between groups (95% confidence interval) | p valuea |
|---|---|---|---|---|
| Primary outcome | ||||
| 6MWT (m) | N = 9 8.05±55.48 |
N= 9 −11.45±49.46 |
19.50 (−33.02–72.02) | 0.443 |
| Secondary outcomes | ||||
| Hemoglobin (g/dL) | N = 9 0.39±0.46 |
N = 10 −0.39±0.85 |
0.78 (0.11–1.45) | 0.026 |
| Geriatric Evaluation Panel | ||||
| Physical function: | ||||
| 4-m walk speed – usual walking speed (m/s) | N = 5 0.420±0.590 |
N = 6 −0.026±0.081 |
0.45 (−0.28–1.17) | 0.167 |
| 4-m walk speed maximum walking speed (m/s) | N = 6 0.413±1.107 |
N = 6 0.093±0.303 |
0.32 (−0.84–1.48) | 0.744 |
| Cognitive function: | ||||
| Trail Making Test Part B seconds per completed circle | N = 9 −0.77±3.54 |
N = 5 −4.96±8.14 |
4.18 (−5.74–14.11) | 0.325 |
| Composite speed of processing Z-score | N = 8 0.62±1.00 |
N = 9 1.08±0.88 |
−0.46 (−1.43–0.51) | 0.330 |
| Composite complex attention/executive processing Z-score | N = 9 0.36±1.28 |
N = 8 0.69±1.19 |
−0.33 (−1.61–0.96) | 0.595 |
| Composite learning and memory Z-score | N = 7 0.41±1.50 |
N = 7 1.39±2.36 |
−0.98 (−3.28–1.33) | 0.374 |
| Quality of life | ||||
| SF-36 physical component summary score | N = 8 −1.89±2.44 |
N = 9 −3.17±10.95 |
1.28 (−7.22–9.78) | 0.741 |
| FACT-An total score | N = 8 10.6±10.0 |
N = 6 0.0±34.7 |
10.6 (−25.7–47.0) | 0.495 |
| Frailty change from frail at baseline to not frail at week 12 | ||||
| Exhaustion | 1/9 (11.1) | 1/8 (12.5) | NA | >0.999 |
| Low energy | 0/7 (0) | 0/5 (0) | NA | NA |
| Weakness | 0/6 (0) | 0/7 (0) | NA | NA |
| Slowness | 0/4 (0) | 0/6 (0) | NA | NA |
Plus-minus values are mean ± SD.
Abbreviations: 6MWT, 6-minute walk test; SF-36, 36-Item Short Form Health Survey; FACT-An, Functional Assessment of Cancer Therapy – Anemia.
a
For the continuous variables, p-values are based on t-tests except for data that were not normally distributed, where Wilcoxon test p-values are reported; for categorical variables, p-values are based on Fisher’s exact tests.