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. 2014 Oct 2;15(1):839. doi: 10.1186/1471-2164-15-839

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© Huang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Expression and localization of bovine COL1A1 and ITIH4 proteins. a, b: The localization and expression of COL1A1 in the healthy cow (HC) and mastitis cow’s (MC) mammary gland tissues by immunohistochemical staining. Brown indicates the positive COL1A1 protein expression; blue presents the negative. d, e: The localization and expression of ITIH4 in the HC and MC group’s mammary gland tissues by immunohistochemical staining. Brown indicates the positive ITIH4 protein; blue presents the negative. c, f: The results of Western blotting reveal the significant increase of COL1A1 and ITIH4 proteins in MC group compared to HC group (p < 0.05).