Table 2.

Clinical findings in the treatment and control group post-treatment

	Number of dogs affected
	Treatment group*	Control group**
Single small and mild skin lesions (scar/papilloma/sore spots/alopecia/erythema/laceration/graze/scab/scaling)	4	7
Small amount of serous eye discharge	2	1
Sinus arrhythmia	1: day 28	(1: day −7)
Loose feces with normal feces	1: day 7	0
Others	1 excess ear wax, 2 dental tartar	1 penile discharge, 1 dental tartar, 1 transient limping

*None of these observations was considered to be treatment related, because a similar incidence occurred in the control group, they were already observed pre-treatment and/or the long interval between treatment and occurrence. All observations were common findings in a dog colony.

**None of these observations was considered to be treatment related, because they were already observed pre-treatment and/or are common findings in a dog colony.