Table 2.

EGFR and K-Ras mutational status

	Descriptive cohort (n = 103)		Correlative cohort (n = 66)		Anti-EGFR treated (n = 39)
	n	%	n	%	n	%
EGFR mutational status
Wild-type	72	70	47	71	24	62
Mutant	31	30	19	29	15	38
Sites of EGFR mutation
Exon 19 deletion	24	77*	14	74*	12	80*
E746_A750del	19	62*	10	54*	8	52*
E746_R748del	1	3*	1	5*	-	-
E746_E749 > Y	1	3*	1	5*	1	7*
L747_A750 > P	1	3*	1	5*	1	7*
L747_T751del	1	3*	1	5*	1	7*
S751_I759del	1	3*	-	-	1	7*
Exon 20 mutation	3	10*	2	10*	-	-
G796D	2	7*	1	5*	-	-
A767_V769dup	1	3*	1	5*	-	-
Exon 21 mutation	4	13*	3	16*	3	20*
L858R	4	13*	3	16*	3	20*
K-Ras mutational status
Wild-type	76	73	46	70	30	77
Mutant	13	13	9	14	4	10
Not evaluable	14	14	11	16	5	13
Sites of K-Ras mutation
Codon 12 mutation	10	77*	7	78*	4	100*
G12C	6	46*	4	44*	3	75*
G12D	1	8*	-	-	-	-
G12V	3	23*	3	34*	1	25*
Codon 13 mutation	3	23*	2	22*	-	-
G13D	3	23*	2	22*	-	-

*Calculated as % of total EGFR and K-Ras mutations in each patient cohort.