Table 1.
CYP26A1 expression and the clinical profiles of the cervical cancer tissue microarray
| CYP26A1 expression | ||||
|---|---|---|---|---|
| Variables | Cases (n) | Negative (%) | Positive (%) | P |
| Age (years) | ||||
| <50 | 21 | 9 (42.9) | 12 (57.1) | 0.022* |
| ≥50 | 29 | 22 (75.9) | 7 (24.1) | |
| Primary tumor status (pT) | ||||
| pTis | 3 | 2 (66.7) | 1 (33.3) | 0.076 |
| pT1a | 7 | 7 (100) | 0 (0) | |
| pT1b | 35 | 18 (51.4) | 17 (48.6) | |
| pT2 | 5 | 4 (80.0) | 1 (20.0) | |
| Lymph node involvement (pN) | ||||
| Absent | 31 | 24 (77.4) | 7 (22.6) | 0.016* |
| Present | 19 | 8 (42.1) | 11 (57.9) | |
| pTNM stage | ||||
| pStage 0 | 3 | 2 (66.7) | 1 (33.3) | 0.061 |
| pStage IA | 7 | 7 (100) | 0 (0) | |
| pStage IB | 20 | 13 (65.0) | 7 (35.0) | |
| pStage II | 1 | 1 (100) | 0 (0) | |
| pStage III | 19 | 8 (42.1) | 11 (57.9) | |
| p53 expression | ||||
| Absent | 44 | 25 (56.8) | 19 (43.2) | 0.071 |
| Present | 6 | 6 (100) | 0 (0) | |
| Ki-67 labeling index | ||||
| <20% | 35 | 25 (71.4) | 10 (28.6) | 0.056 |
| ≥20% | 15 | 6 (40.0) | 9 (60.0) | |
*Significantly different by the chi-square (χ2) test.
Abbreviations: CYP26A1, cytochrome P450, family 26, subfamily A, polypeptide 1; pTNM, pathological tumor-node-metastasis