Table 2. Relative risk of subsequent psoriasis by Mental Health Index score and anti-depression medication use.

	86-100 Non-depressed	76-85	53-75	0-52 (Depressed) or medication use	0-52 (Depressed) and medication use
Self-reported psoriasis
Person-years	137,885	298,564	283,533	88,069	32,624
Psoriasis cases	73	232	245	64	41
Age-adjusted RR (95%CI)	1.00	1.48 (1.14,1.92)	1.65 (1.27,2.14)	1.82 (1.39,2.38)	2.36 (1.61,3.46)
Multivariate-adjusted RR (95%CI)	1.00	1.45 (1.11,1.89)	1.57 (1.21,2.04)	1.59 (1.21,2.08)	1.91 (1.30,2.81)
Confirmed psoriasis
Person-years	137,583	297,669	282,665	87,815	32,446
Psoriasis cases	35	122	130	33	21
Age-adjusted RR (95%CI)	1.0	1.62 (1.11,2.36)	1.83 (1.26,2.66)	1.90 (1.29,2.80)	2.51(1.46.4.31)
Multivariate-adjusted RR (95%CI)	1.0	1.59 (1.09,2.32)	1.75 (1.21,2.55)	1.68 (1.13,2.47)	2.07 (1.20,3.58)

Multivariate models simultaneously controlled for age (continuous), body mass index (<18.5, 18.5-24.9, 25-29.9, 30-34.9, ≥35 kg/m²), alcohol consumption (none, <4.9, 5.0-9.9, 10-14.9, 15-29.9 or ≥30.0 g/d), physical activity (metabolic equivalent hours/wk, quintiles), smoking status (never, current, past). The reference group was women with Mental Health Index score of 86-100 who were also not using anti-depression medications.