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. 2014 Jul 13;16(6):529–542. doi: 10.1016/j.neo.2014.06.001

Figure 1.

Figure 1

MITF and PEDF expression in weakly aggressive and highly aggressive melanoma cell lines. (A) Analysis of MITF and PEDF expression using microarray gene expression data of Mannheim series of melanoma cell lines. Cell lines were classified by their gene signature into weakly and highly aggressive cohorts. Normalized MITF (empty bars) and PEDF (filled bars) signal intensity are plotted across the sample set. (B) Scattergram showing the positive correlation between MITF and PEDF levels in each cohort of the Mannheim series. Statistical significance was determined by Pearson’s test (r = 0.4145; **P < 0.01). (C) Box-plot of MITF (****P < 0.0001) (left) and PEDF (**P < 0.01) (right) expression in weakly and highly aggressive melanoma cell lines of the Mannheim series. Statistical significance was determined by Welch’s test. Boxes in the plots include values in the 25-75% interval; internal lanes represent the median; circles represent outliers. (D) Analysis of MITF and PEDF expression using microarray gene expression data of Philadelphia series of melanoma cell lines. (E) Scattergram showing the positive correlation between MITF and PEDF levels in each cohort of the Philadelphia series. Statistical significance was determined by Spearman’s test (r = 0.4762; *P < 0.05). (F) Box-plot of MITF (Mann-Whitney’s test; ****P < 0.0001) (left) and PEDF (Welch’s test; **P < 0.01) (right) expression in weakly and highly aggressive melanoma cell lines.