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. 2014 Jun 24;16(6):511–528. doi: 10.1016/j.neo.2014.05.009

Figure 7.

Figure 7

CDKN2D up-regulation is not due to a direct epigenetic action of DAC.

(A) CDKN2D mRNA expression levels in K-562 cells cultured in presence of various concentrations of DAC. Data are the mean (±SD) of three independent experiments. * P < 0.05, ** P < 0.01 versus control (one-way ANOVA). (B) Analysis of CDKN2D promoter methylation in K-562 cells treated with DAC. “U” and “M” refer to primers specific for methylated (M) or unmethylated (U) sequences. “UMC”, “MC” and “UC” correspond to unmethylated converted, methylated converted and unconverted unmethylated DNA, respectively. Pictures are representative of three independent experiments.