Table 6.
The top six pathways and their associated genes detected in the organ of Corti
| Pathway | P- value | Gene symbols |
|---|---|---|
| KEGG-pathway analysis | ||
| Toll-like receptor signaling pathway | 7.7E-19 | Traf6, Ifnar1, Irf3, Irf7, Il1b, Irak1, Ly96,Mapk1, Mapk8, Nfkb1, Nfkbia, Spp1, Stat1, Tlr2, Tlr3, Tlr4, Ticam1 |
| Cytokine-cytokine receptor interaction | 3.8E-10 | Bmp2, Cx3cl1, Ifnar1, Ifngr1, Il1b, Il1r1, Il10rb, Il15, Il17a, Il18, Il6ra, Il6st, Tnfsf13b, Tnfrsf11b, Vegfa |
| NOD-like receptor signaling pathway | 6.8E-9 | Traf6, Il1b, Il18, Mapk1, Mapk8, Nfkb1, Nfkbia, Nod1, Nod2 |
| Jak-STAT signaling pathway | 5.4E-8 | Jak2, Ifnar1, Ifngr1, Il10rb, Il15, Il6ra, Il6st, Stat1, Stat6, Stat3, Tyk2 |
| Cytosolic DNA-sensing pathway | 7.3E-8 | Ddx58, Irf3, Irf7, Il1b, Il18, Il33, Nfkb1, Nfkbia |
| RIG-I-like receptor signaling pathway | 6.2E-6 | Ddx58, Traf6, Irf3, Irf7, Mapk8, Nfkb1, Nfkbia |
| Panther-pathway analysis | ||
| Toll-like receptor signaling pathway | 2.2E-14 | Traf6, Irf3, Irf7, Il18, Irak1, Ly96, Mapk1, Mapk8, Nfkb1, Nfkbia, Tlr2, Tlr3, Tlr4, Ticam1 |
| Interleukin signaling pathway | 2.8E-5 | Il10rb, Il15, Il17a, Il18, Il6ra, Il6st, Mapk1, Stat1, Stat6, Stat3 |
| Inflammation mediated by chemokine and cytokine signaling pathway | 3.7E-5 | Jak2, Cx3cl1, Ifnar1, Ifngr1, Il10rb, Il18, Mapk1, Nfkb1, Nfkbia, Stat1, Stat6, Stat3, Tyk2 |
| Interferon-gamma signaling pathway | 3.0E-4 | Jak2, Ifngr1, Mapk1, Mapk8, Stat1 |
| JAK/STAT signaling pathway | 1.5E-3 | Jak2, Stat1, Stat6, Stat3 |
| PDGF signaling pathway | 3.8E-2 | Jak2, Mapk1, Mapk8, Stat1, Stat6, Stat3 |